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Hyaluronic Acid: Production, Properties, Application in Biology and Medicine [2015] [UnitedVRG][PDF]

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Description

 							
  
  Hyaluronic Acid: Preparation, Properties, Application in Biology and
Medicine
  by Author(s): Mikhail A. Selyanin,
Petr Ya. Boykov, Vladimir N. Khabarov, Felix Polyak
  
  
  

 •	Hardcover: 216 pages
  
  •	Publisher: Wiley; 1 edition (March 16, 2015)
  
 
•	Language: English
  
  •	ISBN-13: 9781118633793
  
  •	DOI:
10.1002/9781118695920
  
  Description
  
  Hyaluronic acid is an essential part of
connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a
stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar
industry, as it is believed to be a key factor in fighting the aging process.
  
  Hyaluronic Acid:
Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues
of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research
leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in
nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes
hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the
different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical
means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of
hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5,
the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using
bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift
deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of
modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical
applications of this polysaccharide have been extensively studied and this book provides a wealth of scientific data
demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule.
  
 
Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions,
structure and physical-chemical properties. It will be an invaluable resource to researchers, both industrial and
academic, involved in all aspects of hyaluronan-based technologies. 						

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